Azadirachtin is one of the most widely used botanical insect growth regulators. Because of its structural resemblance to the natural insect molting hormone ecdysone, azadirachtin interrupts molting, metamorphosis, and development of the female reproductive system. Immature insects exposed to azadirachtin (mainly by ingestion) may molt prematurely or die before they can complete a properly timed molt. Those insects that survive a treatment are likely to develop into a deformed adult incapable of feeding, dispersing, or reproducing. Since beneficial insects, predators, and pollinators do not feed directly on the treated foliage, biopesticide insect growth regulators are considered “soft” on beneficial insects such as honeybees, lady bugs, green lacewings, and the parasitic wasps. Due to their unique mode of action, biochemical insect growth regulators have played an important role in integrated pest management systems and as an effective resistance management tool.

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